Clonal dynamics and Stereo-seq resolve origin and phenotypic plasticity of adenosquamous carcinoma.
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ABSTRACT:
SUBMITTER: Zhao R
PROVIDER: S-EPMC10460394 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Publications
Clonal dynamics and Stereo-seq resolve origin and phenotypic plasticity of adenosquamous carcinoma.
Zhao Ruiying R Xu Yunhua Y Chen Yedan Y Zhang Jiajun J Teng Fei F Liao Sha S Chen Shengnan S Wu Qian Q Xiang Chan C Pang Jiaohui J Shang Zhanxian Z Zhao Jikai J Bao Hairong H Bao Hua H Shao Yang Y Lu Shun S Han Yuchen Y
NPJ precision oncology 20230826 1
The genomic origin and development of the biphasic lung adenosquamous carcinoma (ASC) remain inconclusive. Here, we derived potential evolutionary trajectory of ASC through whole-exome sequencing, Stereo-seq, and patient-derived xenografts. We showed that EGFR and MET activating mutations were the main drivers in ASCs. Phylogenetically, these drivers and passenger mutations found in both components were trunk clonal events, confirming monoclonal origination. Comparison of multiple lesions also r ...[more]
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