The timing of geographic power.

ABSTRACT: In many studies on the spatial risk of disease, investigators use geographic locations at the time of disease diagnosis in spatial models to search for individual areas of elevated risk. However, these studies often fail to find a significant spatial signal. This may be due to the misspecification of the timing and location of pertinent exposures. Environmental exposures related to cancer risk vary over space and time, and many cancers have long latencies. When these factors are considered in conjunction with a mobile population, it is likely that the spatial signal related to relevant historic environmental exposures is obscured. To investigate this hypothesis, we conducted simulation studies to characterize the effect of residential mobility on the ability of generalized additive models

SUBMITTER: Joseph AC 

PROVIDER: S-EPMC10460512 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature