Neighborhood-based inference and restricted Boltzmann machine for small molecule-miRNA associations prediction.

ABSTRACT:

Background

A growing number of experiments have shown that microRNAs (miRNAs) can be used as target of small molecules (SMs) to regulate gene expression for treating diseases. Therefore, identifying SM-related miRNAs is helpful for the treatment of diseases in the domain of medical investigation.

Methods

This article presents a new computational model, called NIRBMSMMA (neighborhood-based inference (NI) and restricted Boltzmann machine (RBM)), which we developed to identify potential small molecule-miRNA associations (NIRBMSMMA). First, grounded on known SM-miRNAs associations, SM similarity and miRNA similarity, NI was used to predict score of an unknown SM-miRNA pair by reckoning the sum of known associations between neighbors of the SM (miRNA) and the miRNA (SM). Second,

SUBMITTER: Qu J 

PROVIDER: S-EPMC10460564 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature