Recombinant Neorudin for the Prevention of Deep-Vein Thrombosis After Spinal-Cord Injury.

ABSTRACT:

Background

Whether anticoagulant therapy should be used after spinal-cord injury (SCI) surgery was controversial. The anticoagulation characteristics of a newly developed anticoagulant, recombinant neorudin (EPR-hirudin (EH)), were explored using a rat model of SCI to provide a basis for clinical anticoagulation therapy of SCI.

Methods

A rat model of SCI was developed by Allen's method. Then, thrombosis in the inferior vena cava was induced by ligation. The low-bleeding characteristics of EH were explored by investigating dose-response and time-effect relationships, as well as multiple administration of EH, on thrombus formation complicated with SCI.

Results

EH inhibited thrombosis in a dose-dependent manner by reducing the wet weight and dry weight of the thrombus. A

SUBMITTER: Liu YB 

PROVIDER: S-EPMC10460582 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature