Analysis of retest reliability for pregnant women undergoing cfDNA testing with a no-call result.

ABSTRACT:

Background

Determining the reasons for unreportable or no-call cell-free DNA (cfDNA) test results has been an ongoing issue, and a consensus on subsequent management is still lacking. This study aimed to explore potential factors related to no-call cfDNA test results and to discuss whether retest results are reliable.

Methods and results

This was a retrospective study of women with singleton pregnancies undergoing cfDNA testing in 2021. Of the 9871 pregnant patients undergoing cfDNA testing, 111 had a no-call result, and their results were compared to those of 170 control patients. The no-call rate was 1.12% (111/9871), and the primary cause for no-call results was data fluctuation (88.29%, 98/111). Medical conditions were significantly more frequent in the no-call group tha

SUBMITTER: He S 

PROVIDER: S-EPMC10460704 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature