Impact of gut Microbiome alteration in Ulcerative Colitis patients on disease severity and outcome.

ABSTRACT:

Background

Ulcerative colitis is a heterogeneous disease in terms of disease course, location, and therapeutic response. The current study was done to assess the alteration of the gut microbiome in UC patients and its relationship to severity, response to therapy, and outcome.

Patients and methods

The study included 96 participants who were divided into a case group (n = 48, recent onset, treatment naive ulcerative colitis patients who were subdivided into mild, moderate, and severe subgroups based on Truelove-Witts and endoscopic severity) and a healthy control group (n = 48). All were subjected to a thorough history, clinical examination, colonoscopy, routine laboratory tests, and quantitative real-time PCR to quantify Bacteroides, Lactobacilli, Faecalibacterium prausnitzi

SUBMITTER: Basha OM 

PROVIDER: S-EPMC10460709 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature