NCX1 disturbs calcium homeostasis and promotes RANKL-induced osteoclast differentiation by regulating JNK/c-Fos/NFATc1 signaling pathway in multiple myeloma.

ABSTRACT: Although several types of calcium channels abnormalities have been shown to promote myeloma bone disease (MBD), the relationship between Na⁺/Ca²⁺ exchanger 1 (NCX1) and MBD remains unexplored. Here, we examined the role of NCX1 in the development of multiple myeloma (MM), with a special focus on the underlying effects involved osteoclast differentiation. Firstly, we detected NCX1 protein highly expressed in BM tissues of MM patients, and its expression was positively correlated with serum calcium and the percentage of BM CD138⁺ cells. In vitro, NCX1 suppression with the inhibitor KB-R7943 reduced cell viability of MM cells and caused apoptosis. Extracellular high Ca²⁺ environment increased the level of intracellular Ca²⁺ in MM cells th

SUBMITTER: Li T 

PROVIDER: S-EPMC10460717 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature