Regulation and function of adiponectin in the intestinal epithelial cells in response to Trichinella spiralis infection.

ABSTRACT: Besides metabolic homeostasis regulation, adipokines are recently emerged as important players in regulating immunity and inflammation. Helminth infection has known to modulate circulating adipokine secretion; however, the regulation and function of adipokines in response to helminth infection is still unclear. Here, we investigated the regulation and function of adiponectin during T. spiralis infection. While there was no change in circulating level of adiponectin, we found an increased adiponectin, but not leptin expression in the small intestine. Interestingly, the intestinal adiponectin expression was strongly associated with the expression of epithelial cell-derived cytokines IL-25, IL-33, and TSLP following infection. Indeed, mice deficiency of IL-25 receptor exhibited no intestinal

SUBMITTER: Jeerawattanawart S 

PROVIDER: S-EPMC10460792 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature