Designing Potent Anticancer Peptides by Aurein 1.2 Key Residues Mutation and Catenate Cell-Penetrating Peptide.

ABSTRACT:

Purpose

Aurein 1.2 (Aur) peptide is known for possessing anticancer characteristics devoid of conventional therapeutics side effects. For improving Aur peptide anticancer functionality, different anticancer peptides were constructed based on Aur peptide through targeting two separate strategies, including (1) sequence-based mutations and (2) adding a cell-penetrating peptide linker.

Methods

The study was approached by designing three different analogs of Aur, including (a) Aur mutant (Aur_m), (b) Aur with N-terminal polyarginine linker (R5-Aur), and (c) Aur_m with R5 (R5-Aur_m). Computational molecular dynamics simulations clearly showed higher structural stability of R5-Aur and R5-Aur_m compared to Aur, solely. The α-helical propertie

SUBMITTER: Salarpour Garnaie H 

PROVIDER: S-EPMC10460806 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature