False discovery rate-controlled multiple testing for union null hypotheses: a knockoff-based approach.

ABSTRACT: False discovery rate (FDR) controlling procedures provide important statistical guarantees for replicability in signal identification based on multiple hypotheses testing. In many fields of study, FDR controling procedures are used in high-dimensional (HD) analyses to discover features that are truly associated with the outcome. In some recent applications, data on the same set of candidate features are independently collected in multiple different studies. For example, gene expression data are collected at different facilities and with different cohorts, to identify the genetic biomarkers of multiple types of cancers. These studies provide us with opportunities to identify signals by considering information from different sources (with potential heterogeneity) jointly. This paper is about

SUBMITTER: Dai R 

PROVIDER: S-EPMC10460825 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature