Cytoreductive Nephrectomy for Patients with Metastatic Sarcomatoid and/or Rhabdoid Renal Cell Carcinoma Treated with Immune Checkpoint Therapy.

ABSTRACT:

Background

Renal cell carcinoma (RCC) with sarcomatoid and/or rhabdoid (S/R) dedifferentiation is a highly aggressive tumor with a poor prognosis. Immune checkpoint therapy (ICT) has shown significant treatment efficacy in this subtype. There remains uncertainly regarding the role of cytoreductive nephrectomy (CN) for patients with metastatic RCC (mRCC) with S/R who received ICT.

Objective

Here, we report the outcomes with ICT for patients with mRCC and S/R dedifferentiation by CN status.

Design, setting, and participants

A retrospective review was conducted of 157 patients with sarcomatoid, rhabdoid, or sarcomatoid plus rhabdoid dedifferentiation who received an ICT-based regimen at two cancer centers.

Intervention

CN performed at any time point; nephrectomy w

SUBMITTER: Hahn AW 

PROVIDER: S-EPMC10460829 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature