Antithrombin Deficiency Is Associated with Prothrombotic Plasma Fibrin Clot Phenotype.

ABSTRACT:

Background

 Deficiency of antithrombin increases risk of venous thromboembolism. We hypothesized that antithrombin deficiency affects fibrin clot structure and function.

Methods

 We evaluated 148 patients (age: 38 [32-50] years; 70% women) with genetically confirmed antithrombin deficiency and 50 healthy controls. Fibrin clot permeability (K_s) and clot lysis time (CLT) along with thrombin generation capacity were assessed before and after antithrombin activity normalization in vitro.

Results

 Antithrombin-deficient patients had lower antithrombin activity (-39%) and antigen levels (-23%) compared with controls (both p < 0.01). Prothrombin fragment 1 + 2 levels were 26.5% higher in patients with antithrombin deficiency than in controls along with 94%

SUBMITTER: Natorska J 

PROVIDER: S-EPMC10460956 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature