Cerebrovascular integrity affects gradients of aging-related dopamine D1 differences in the striatum.

ABSTRACT: Extant research suggest aging-related losses of different dopaminergic markers, including presynaptic dopamine transporters as well as post-synaptic DA receptors. Given the central role of DA in neurocognitive functions, maintenance of a healthy DA system may be a key to mitigate age-related cognitive decline. Mechanisms behind DA losses in aging are however largely uncharted. Past research documented an association between dopaminergic integrity and cerebrovascular health (via white matter lesion volumes). However, it remains unclear whether proximity to lesions affected the spatial patterns of age-related D1DR differences within the striatum, and whether such differences are related to mnemonic function. Here, a large cohort of middle-aged to older healthy participants (age = 40-80 years

SUBMITTER: Johansson J 

PROVIDER: S-EPMC10460986 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature