Ultrastructure for the diagnosis of primary ciliary dyskinesia in South Africa, a resource-limited setting.

ABSTRACT:

Introduction

International guidelines recommend a multi-faceted approach for successful diagnoses of primary ciliary dyskinesia (PCD). In the absence of a gold standard test, a combination of genetic testing/microscopic analysis of structure and function/nasal nitric oxide measurement is used. In resource-limited settings, often none of the above tests are available, and in South Africa, only transmission electron microscopy (TEM) is available in central anatomical pathology departments. The aim of this study was to describe the clinical and ultrastructural findings of suspected PCD cases managed by pediatric pulmonologists at a tertiary-level state funded hospital in Johannesburg.

Methods

Nasal brushings were taken from 14 children with chronic respiratory symptoms in keepi

SUBMITTER: Birkhead M 

PROVIDER: S-EPMC10461090 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature