An unusual case of rapid resolution of bilateral vitelliform deposits after discontinuation of pentosan polysulfate sodium.

ABSTRACT:

Purpose

To report the structural and functional changes in a 67-year-old male with pentosan polysulfate sodium (PPS) maculopathy with a progressive resolution of bilateral vitelliform lesions after PPS cessation.

Observations

The patient was initially seen after taking daily PPS for over 26 years. Three months after discontinuing PPS, the bilateral vitelliform lesions identified on spectral-domain optical coherence tomography (SD-OCT) at initial consultation had completely resolved. Bilateral resolution of vitelliform lesions was associated with a decline in best-corrected visual acuity, and ellipsoid zone disruption on SD-OCT.

Conclusions and importance

Several PPS maculopathy phenotypes have been previously described including vitelliform lesions. Our case highlight

SUBMITTER: Kalaw FGP 

PROVIDER: S-EPMC10461119 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature