Comparisons of PNEC derivation logic flows under example regulatory schemes and implications for ecoTTC.

ABSTRACT: Derivation of Predicted No Effect Concentrations (PNECs) for aquatic systems is the primary deterministic form of hazard extrapolation used in environmental risk assessment. Depending on the data availability, different regulatory jurisdictions apply application factors (AFs) to the most sensitive measured endpoint to derive the PNEC for a chemical. To assess differences in estimated PNEC values, two PNEC determination methodologies were applied to a curated public database using the EnviroTox Platform (www.EnviroToxdatabase.org). PNECs were derived for 3647 compounds using derivation procedures based on example US EPA and a modified European Union chemical registration procedure to allow for comparisons. Ranked probability distributions of PNEC values were developed and 5th percentile val

SUBMITTER: Belanger SE 

PROVIDER: S-EPMC10461128 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature