Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin.

ABSTRACT: Mucosal-associated invariant T (MAIT) cells represent an abundant innate-like T cell subtype in the human liver. MAIT cells are assigned crucial roles in regulating immunity and inflammation, yet their role in liver cancer remains elusive. Here, we present a MAIT cell-centered profiling of hepatocellular carcinoma (HCC) using scRNA-seq, flow cytometry, and co-detection by indexing (CODEX) imaging of paired patient samples. These analyses highlight the heterogeneity and dysfunctionality of MAIT cells in HCC and their defective capacity to infiltrate liver tumors. Machine-learning tools were used to dissect the spatial cellular interaction network within the MAIT cell neighborhood. Co-localization in the adjacent liver and interaction between niche-occupying CSF1R⁺PD-L1⁺

SUBMITTER: Ruf B 

PROVIDER: S-EPMC10461130 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature