Reflex voiding in rat occurs at consistent bladder volume regardless of pressure or infusion rate.

ABSTRACT:

Aims

The central nervous system (CNS) regulates lower urinary tract reflexes using information from sensory afferents; however, the mechanisms of this process are not well known. Pressure and volume were measured at the onset of the guarding and micturition reflexes across a range of infusion rates to provide insight into what the CNS is gauging to activate reflexes.

Methods

Female Sprague Dawley rats were anesthetized with urethane for open outlet cystometry. A set of 10 infusion rates (ranging 0.92-65.5 mL/h) were pseudo-randomly distributed across 30 single-fill cystometrograms. Bladder pressure and external urethral sphincter electromyography were used for the determination of the onset of the micturition and guarding reflexes, respectively. The bladder volume at the ons

SUBMITTER: Jaskowak DJ 

PROVIDER: S-EPMC10461254 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature