Molecular Mechanisms of PTH/PTHrP Class B GPCR Signaling and Pharmacological Implications.

ABSTRACT: The classical paradigm of G protein-coupled receptor (GPCR) signaling via G proteins is grounded in a view that downstream responses are relatively transient and confined to the cell surface, but this notion has been revised in recent years following the identification of several receptors that engage in sustained signaling responses from subcellular compartments following internalization of the ligand-receptor complex. This phenomenon was initially discovered for the parathyroid hormone (PTH) type 1 receptor (PTH1R), a vital GPCR for maintaining normal calcium and phosphate levels in the body with the paradoxical ability to build or break down bone in response to PTH binding. The diverse biological processes regulated by this receptor are thought to depend on its capacity to mediate diver

SUBMITTER: Vilardaga JP 

PROVIDER: S-EPMC10461325 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature