Association between TFEB gene polymorphism, gene-environment interaction, and fatty liver disease: A case-control study in China.

ABSTRACT:

Background

Fatty liver disease (FLD) is a serious public health problem that is rapidly increasing. Evidence indicates that the transcription factor EB (TFEB) gene may be involved in the pathophysiology of FLD; however, whether TEFB polymorphism has an association with FLD remains unclear.

Objectives

To explore the association among TFEB polymorphism, gene-environment interaction, and FLD and provide epidemiological evidence for clarifying the genetic factors of FLD.

Methods

This study is a case-control study. Sequenom MassARRAY was applied in genotyping. Logical regression was used to analyze the association between TFEB polymorphism and FLD, and the gene-environment interaction in FLD was evaluated by multiplication and additive interacti

SUBMITTER: Mo C 

PROVIDER: S-EPMC10461375 | biostudies-literature | 2021 Jul-Sep

REPOSITORIES: biostudies-literature