Characterization of endoplasmic reticulum-associated degradation in the human fungal pathogen Candida albicans.

ABSTRACT:

Background

Candida albicans is the most prevalent human fungal pathogen. In immunocompromised individuals, C. albicans can cause serious systemic disease, and patients infected with drug-resistant isolates have few treatment options. The ubiquitin-proteasome system has not been thoroughly characterized in C. albicans. Research from other organisms has shown ubiquitination is important for protein quality control and regulated protein degradation at the endoplasmic reticulum (ER) via ER-associated protein degradation (ERAD).

Methods

Here we perform the first characterization, to our knowledge, of ERAD in a human fungal pathogen. We generated functional knockouts of C. albicans genes encoding three proteins predicted to play roles in ERAD, th

SUBMITTER: Doss EM 

PROVIDER: S-EPMC10461541 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature