Differentiation value of miR-26b for major depressive disorder, schizophrenia, generalized anxiety disorder.

ABSTRACT:

Introduction

First episode and drug naive schizophrenia (SZ) patients comorbid with major depressive episode and generalized anxiety disorder (GAD) comorbid with major depressive disorder (MDD) are common in clinical practice, overlapping symptomatology during first presentation of MDD, SZ and GAD challenged the diagnostic process.

Materials and methods

This study aimed to investigate the differentiation value of peripheral microRNA-26b expression in 52 patients of MDD, SZ, and GAD, respectively, and 52 controls. Quantitative real-time reverse transcription polymerase chain reaction was used to further verify aberrant miRNAs of previous identified in MDD and investigate expression level of these peripheral miRNAs in SZ and GAD.

Results

The expression levels of miR-26b

SUBMITTER: Kong L 

PROVIDER: S-EPMC10461581 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature