Selective depolarization of transmembrane potential alters muscle patterning and muscle cell localization in Xenopus laevis embryos.

ABSTRACT: The correct anatomical placement and precise determination of specific cell types is required for the establishment of normal embryonic patterning. Understanding these processes is also important for progress in regenerative medicine and cancer biology. Transmembrane voltage gradients across embryonic tissues can mediate cellular communication to regulate the processes of proliferation, migration, and differentiation. Our past work showed that selective depolarization of an endogenous instructor cell population in Xenopus laevis in vivo induced a melanoma-like phenotype in the absence of genetic damage. Here, we use a hypersensitive glycine-gated chloride channel (GlyR) under control of tissue-specific promoters to show that instructor cells resident within muscle are more effective at tri

SUBMITTER: Lobikin M 

PROVIDER: S-EPMC10461602 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature