The impact of innate immunity on malaria parasite infection dynamics in rodent models.

ABSTRACT: Decades of research have probed the molecular and cellular mechanisms that control the immune response to malaria. Yet many studies offer conflicting results on the functional impact of innate immunity for controlling parasite replication early in infection. We conduct a meta-analysis to seek consensus on the effect of innate immunity on parasite replication, examining three different species of rodent malaria parasite. Screening published studies that span four decades of research we collate, curate, and statistically analyze infection dynamics in immune-deficient or -augmented mice to identify and quantify general trends and reveal sources of disagreement among studies. Additionally, we estimate whether host factors or experimental methodology shape the impact of immune perturbations on

SUBMITTER: Herbert Mainero A 

PROVIDER: S-EPMC10461630 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature