Peripheral Nerve Matrix Hydrogel Promotes Recovery after Nerve Transection and Repair.

ABSTRACT:

Background

Nerve transection is the most common form of peripheral nerve injury. Treatment of peripheral nerve injury has primarily focused on stabilization and mechanical cues to guide extension of the regenerating growth cone across the site of transection. The authors investigated the effects of a peripheral nerve matrix (PNM) hydrogel on recovery after nerve transection.

Methods

The authors used rodent models to determine the effect of PNM on axon extension, electrophysiologic nerve conduction, force generation, and neuromuscular junction formation after nerve transection and repair. The authors complemented this work with in vivo and in vitro fluorescence-activated cell sorting and immunohistochemistry approaches to determine the effects of PNM on critical cell populati

SUBMITTER: Bernard M 

PROVIDER: S-EPMC10461719 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature