Mapping the development of the basal ganglia in children with attention-deficit/hyperactivity disorder.

ABSTRACT:

Objective

The basal ganglia are implicated in the pathophysiology of attention-deficit/hyperactivity disorder (ADHD), but little is known of their development in the disorder. Here, we mapped basal ganglia development from childhood into late adolescence using methods that define surface morphology with an exquisite level of spatial resolution.

Method

Surface morphology of the basal ganglia was defined from neuroanatomic magnetic resonance images acquired in 270 youth with DSM-IV-defined ADHD and 270 age- and sex-matched typically developing controls; 220 individuals were scanned at least twice. Using linear mixed model regression, we mapped developmental trajectories from age 4 through 19 years at approximately 7,500 surface vertices in the striatum and globus pallidus.

SUBMITTER: Shaw P 

PROVIDER: S-EPMC10461726 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature