Neonatal exposure to sevoflurane caused learning and memory impairment via dysregulating SK2 channel endocytosis.

ABSTRACT: Numerous studies have demonstrated that anesthetics' exposure to neonates imposes toxicity on the developing brain but the underlying mechanisms need to be further elucidated. Our present study aimed to explore the role of small conductance Ca²⁺-activated potassium channel type2 in memory and learning dysfunction caused by exposing neonates to sevoflurane. Postnatal day 7 Sprague-Dawley rats and hemagglutinin-tagged small conductance Ca²⁺-activated potassium channel type2 channel transfected COS-7 cells were exposed to sevoflurane and the trafficking of small conductance Ca²⁺-activated potassium channel type2 channels was analyzed; furthermore, memory and learning ability was analyzed by the Morris water maze test on postnatal day30-35 (juvenile period). Ou

SUBMITTER: Ke W 

PROVIDER: S-EPMC10461796 | biostudies-literature | 2021 Jul-Sep

REPOSITORIES: biostudies-literature