Two-way feedback between chromatin compaction and histone modification state explains S. cerevisiae heterochromatin bistability.

ABSTRACT: Compact chromatin is closely linked with gene silencing in part by sterically masking access to promoters, inhibiting transcription factor binding and preventing polymerase from efficiently transcribing a gene. Here, we propose a broader view: chromatin compaction can be both a cause and a consequence of the histone modification state, and this tight bidirectional interaction can underpin bistable transcriptional states. To test this theory, we developed a mathematical model for the dynamics of the HMR locus in S. cerevisiae , that incorporates activating histone modifications, silencing proteins and a dynamic, acetylation-dependent, three-dimensional locus size. Chromatin compaction enhances silencer protein binding, which in turn feeds back to remove activating histone modificatio

SUBMITTER: Movilla Miangolarra A 

PROVIDER: S-EPMC10461966 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature