Flexible regulation of representations on a drifting manifold enables long-term stable complex neuroprosthetic control.

ABSTRACT: The nervous system needs to balance the stability of neural representations with plasticity. It is unclear what is the representational stability of simple actions, particularly those that are well-rehearsed in humans, and how it changes in new contexts. Using an electrocorticography brain-computer interface (BCI), we found that the mesoscale manifold and relative representational distances for a repertoire of simple imagined movements were remarkably stable. Interestingly, however, the manifold's absolute location demonstrated day-to-day drift. Strikingly, representational statistics, especially variance, could be flexibly regulated to increase discernability during BCI control without somatotopic changes. Discernability strengthened with practice and was specific to the BCI, demonstratin

SUBMITTER: Natraj N 

PROVIDER: S-EPMC10462094 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature