Chromatin-associated cohesin turns over extensively and forms new cohesive linkages during meiotic prophase.

ABSTRACT: In dividing cells, accurate chromosome segregation depends on sister chromatid cohesion, protein linkages that are established during DNA replication. Faithful chromosome segregation in oocytes requires that cohesion, first established in S phase, remain intact for days to decades, depending on the organism. Premature loss of meiotic cohesion in oocytes leads to the production of aneuploid gametes and contributes to the increased incidence of meiotic segregation errors as women age (maternal age effect). The prevailing model is that cohesive linkages do not turn over in mammalian oocytes. However, we have previously reported that cohesion-related defects arise in Drosophila oocytes when individual cohesin subunits or cohesin regulators are knocked down after meiotic S phase. Here we use tw

SUBMITTER: Haseeb MA 

PROVIDER: S-EPMC10462139 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature