The microenvironment dictates glycocalyx construction and immune surveillance.
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ABSTRACT:
SUBMITTER: Tharp KM
PROVIDER: S-EPMC10462183 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Publications
The microenvironment dictates glycocalyx construction and immune surveillance.
Tharp Kevin M KM Park Sangwoo S Timblin Greg A GA Richards Alicia L AL Berg Jordan A JA Twells Nicholas M NM Riley Nicholas M NM Peltan Egan L EL Shon D Judy DJ Stevenson Erica E Tsui Kimberly K Palomba Francesco F Lefebvre Austin E Y T AEYT Soens Ross W RW Ayad Nadia M E NME Hoeve-Scott Johanna Ten JT Healy Kevin K Digman Michelle M Dillin Andrew A Bertozzi Carolyn R CR Swaney Danielle L DL Mahal Lara K LK Cantor Jason R JR Paszek Matthew J MJ Weaver Valerie M VM
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Efforts to identify anti-cancer therapeutics and understand tumor-immune interactions are built with <i>in vitro</i> models that do not match the microenvironmental characteristics of human tissues. Using <i>in vitro</i> models which mimic the physical properties of healthy or cancerous tissues and a physiologically relevant culture medium, we demonstrate that the chemical and physical properties of the microenvironment regulate the composition and topology of the glycocalyx. Remarkably, we find ...[more]
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