Bioactive glycans in a microbiome-directed food for malnourished children.

ABSTRACT: Evidence is accumulating that perturbed postnatal development of the gut microbiome contributes to childhood malnutrition^1-4. Designing effective microbiome-directed therapeutic foods to repair these perturbations requires knowledge about how food components interact with the microbiome to alter its expressed functions. Here we use biospecimens from a randomized, controlled trial of a microbiome-directed complementary food prototype (MDCF-2) that produced superior rates of weight gain compared to a conventional ready-to-use supplementary food (RUSF) in 12-18-month-old Bangladeshi children with moderate acute malnutrition (MAM)4. We reconstructed 1000 bacterial genomes (metagenome-assembled genomes, MAGs) present in their fecal microbiomes, identified 75 whose abundances were pos

SUBMITTER: Hibberd MC 

PROVIDER: S-EPMC10462212 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature