Timing dependent synergies between motor cortex and posterior spinal stimulation in humans.

ABSTRACT: Volitional movement requires descending input from motor cortex and sensory feedback through the spinal cord. We previously developed a paired brain and spinal electrical stimulation approach in rats that relies on convergence of the descending motor and spinal sensory stimuli in the cervical cord. This approach strengthened sensorimotor circuits and improved volitional movement through associative plasticity. In humans it is not known whether dorsal epidural SCS targeted at the sensorimotor interface or anterior epidural SCS targeted within the motor system is effective at facilitating brain evoked responses. In 59 individuals undergoing elective cervical spine decompression surgery, the motor cortex was stimulated with scalp electrodes and the spinal cord with epidural electrodes while m

SUBMITTER: McIntosh JR 

PROVIDER: S-EPMC10462218 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature