Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells.

ABSTRACT: The progressive death of mature neurons often results in neurodegenerative diseases. While the previous studies have mostly focused on identifying intrinsic mechanisms controlling neuronal survival, the extracellular environment also plays a critical role in regulating cell viability. Here we explore how intercellular communication contributes to the survival of retinal ganglion cells (RGCs) following the optic nerve crush (ONC). Although the direct effect of the ONC is restricted to the RGCs, we observed transcriptomic responses in other retinal cells to the injury based on the single-cell RNA-seq, with astrocytes and Müller glia having the most interactions with RGCs. By comparing the RGC subclasses showing distinct resilience to ONC-induced cell death, we found that the high-survival RG

SUBMITTER: Qian C 

PROVIDER: S-EPMC10462234 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature