Self-Powered Programming of Fibroblasts into Neurons via a Scalable Magnetoelastic Generator Array.

ABSTRACT: Developing scalable electrical stimulating platforms for cell and tissue engineering applications is limited by external power source dependency, wetting resistance, microscale size requirements, and suitable flexibility. Here, a versatile and scalable platform is developed to enable tunable electrical stimulation for biological applications by harnessing the giant magnetoelastic effect in soft systems, converting gentle air pressure (100-400 kPa) to yield a current of up to 10.5 mA and a voltage of 9.5 mV. The platform can be easily manufactured and scaled up for integration in multiwell magnetoelastic plates via 3D printing. The authors demonstrate that the electrical stimulation generated by this platform enhances the conversion of fibroblasts into neurons up to 2-fold (104%) and subseq

SUBMITTER: Libanori A 

PROVIDER: S-EPMC10462379 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature