Dysfunctional high-density lipoprotein in chronic inflammatory rheumatic diseases.

ABSTRACT:

Background

The mechanism explaining low cholesterol concentrations in chronic inflammatory rheumatic disease (CIRD) is incompletely understood. We hypothesized that chronic inflammation impairs the functionality of high-density lipoprotein (HDL), for example, by oxidative processes.

Objectives

Assessment of oxidized HDL (HDL_ox), a marker of dysfunctional HDL, in newly diagnosed patients with CIRD before and after initiation of immunosuppressive therapy and comparison of HDL_ox values of patients with CIRD to non-CIRD controls.

Design

Prospective observational trial.

Methods

The study was conducted on 44 newly diagnosed CIRD patients, who were initiated on immunosuppressive therapy (baseline). A total of 136 patients without CIRD served as c

SUBMITTER: Waldecker-Gall S 

PROVIDER: S-EPMC10462425 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature