Efficacy of intrathecal methotrexate in children with high-risk medulloblastoma over three years: a retrospective study from a single center.

ABSTRACT:

Purpose

Chemotherapy is commonly used for treatment in children over three years old with high-risk medulloblastoma(MB). However, little is currently known about the therapeutic benefits and side effects of intrathecal methotrexate(MTX), warranting further research.

Methods

In this retrospective study, patients who received intrathecal MTX during chemotherapy were included in the MTX group (n = 32), and patients that only underwent cerebrospinal fluid (CSF) cytology analysis were assigned to the control group (n = 14).

Results

In the MTX group, 27(84.38%) patients had metastatic disease, 3(9.38%) had diffuse anaplasia, and 3(9.38%) had residual disease greater than 1.5 cm². Molecular subgroup classification was available for 28(87.5%) patients. In the contr

SUBMITTER: Zhang YT 

PROVIDER: S-EPMC10462507 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature