Signal-transducing adaptor protein 1 (STAP1) in microglia promotes the malignant progression of glioma.

ABSTRACT:

Background

Glioma is the most malignant primary brain tumor with a poor survival time. The tumour microenvironment, especially glioma-associated microglia/macrophages (GAMs), plays an important role in the pathogenesis of glioma. Currently, microglia (CD11b⁺/CD45^Low) and macrophages (CD11b⁺/CD45^High) are distinguished as distinct cell types due to their different origins. Moreover, signal-transducing adaptor protein 1 (STAP1) plays a role in tumourigenesis and immune responses. However, to date, no studies have been reported on STAP1 in GAMs.

Methods

The Cancer Genome Atlas and Chinese Glioma Genome Atlas databases were used to investigate the association between STAP1 mRNA levels and clinical parameters (grades, mutations in isoci

SUBMITTER: Yang X 

PROVIDER: S-EPMC10462508 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature