Intragenomic rDNA variation - the product of concerted evolution, mutation, or something in between?

ABSTRACT: The classical model of concerted evolution states that hundreds to thousands of ribosomal DNA (rDNA) units undergo homogenization, making the multiple copies of the individual units more uniform across the genome than would be expected given mutation frequencies and gene redundancy. While the universality of this over 50-year-old model has been confirmed in a range of organisms, advanced high throughput sequencing techniques have also revealed that rDNA homogenization in many organisms is partial and, in rare cases, even apparently failing. The potential underpinning processes leading to unexpected intragenomic variation have been discussed in a number of studies, but a comprehensive understanding remains to be determined. In this work, we summarize information on variation or polymorphism

SUBMITTER: Wang W 

PROVIDER: S-EPMC10462631 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature