Surface frustration re-patterning underlies the structural landscape and evolvability of fungal orphan candidate effectors.

ABSTRACT: Pathogens secrete effector proteins to subvert host physiology and cause disease. Effectors are engaged in a molecular arms race with the host resulting in conflicting evolutionary constraints to manipulate host cells without triggering immune responses. The molecular mechanisms allowing effectors to be at the same time robust and evolvable remain largely enigmatic. Here, we show that 62 conserved structure-related families encompass the majority of fungal orphan effector candidates in the Pezizomycotina subphylum. These effectors diversified through changes in patterns of thermodynamic frustration at surface residues. The underlying mutations tended to increase the robustness of the overall effector protein structure while switching potential binding interfaces. This mechanism could expla

SUBMITTER: Derbyshire MC 

PROVIDER: S-EPMC10462633 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature