α-Synuclein pathology in post-mortem retina and optic nerve is specific for α-synucleinopathies.

ABSTRACT: There is increasing interest in studying retinal biomarkers for various neurodegenerative diseases. Specific protein aggregates associated with neurodegenerative diseases are present in the retina and could be visualised in a non-invasive way. This study aims to assess the specificity and sensitivity of retinal α-synuclein aggregates in neuropathologically characterised α-synucleinopathies, other neurodegenerative diseases and non-neurological controls. Post-mortem eyes (N = 99) were collected prospectively through the Netherlands Brain Bank from donors with Parkinson's disease (and dementia), dementia with Lewy bodies, multiple system atrophy, Alzheimer's disease, other neurodegenerative diseases and non-neurological controls. Multiple retinal and optic nerve cross-sections were immunosta

SUBMITTER: Hart de Ruyter FJ 

PROVIDER: S-EPMC10462645 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature