Kinetic resolution of substituted amido[2.2]paracyclophanes via asymmetric electrophilic amination.

ABSTRACT: Planar chiral [2.2]paracyclophane derivatives are a type of structurally intriguing and practically useful chiral molecules, which have found a range of important applications in the field of asymmetric catalysis and material science. However, access to enantioenriched [2.2]paracyclophanes represents a longstanding challenge in organic synthesis due to their unique structures, which are still highly dependent on the chiral chromatography separation technique and classical chemical resolution strategy to date. In this work, we report on an efficient and versatile kinetic resolution protocol for various substituted amido[2.2]paracyclophanes, including those with pseudo-geminal, pseudo-ortho, pseudo-meta and pseudo-para disubstitutions, using chiral phosphoric acid (CPA)-catalyzed asymmetric

SUBMITTER: Yu S 

PROVIDER: S-EPMC10462673 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature