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COPS6 promotes tumor progression and reduces CD8⁺ T cell infiltration by repressing IL-6 production to facilitate tumor immune evasion in breast cancer.

ABSTRACT: Due to poor T cell infiltration, tumors evade immune surveillance. Increased CD8⁺ T cell infiltration in breast cancer suggests a satisfactory response to immunotherapy. COPS6 has been identified as an oncogene, but its role in regulating antitumor immune responses has not been defined. In this study, we investigated the impact of COPS6 on tumor immune evasion in vivo. Tumor transplantation models were established in C57BL/6 J mice and BALB/c nude mice. Flow cytometry was conducted to identify the role of COPS6 on tumor-infiltrating CD8⁺ T cells. By analyzing the TCGA and GTEx cohort, we found that COPS6 expression was significantly up-regulated in a variety of cancers. In human osteosarcoma cell line U2OS and non-small cell lung cancer cell line H1299, we showed that

SUBMITTER: Du WQ

PROVIDER: S-EPMC10462724 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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COPS6 promotes tumor progression and reduces CD8⁺ T cell infiltration by repressing IL-6 production to facilitate tumor immune evasion in breast cancer.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

COPS6 promotes tumor progression and reduces CD8+ T cell infiltration by repressing IL-6 production to facilitate tumor immune evasion in breast cancer.

OmicsDI is part of the ELIXIR infrastructure

Tweets

COPS6 promotes tumor progression and reduces CD8⁺ T cell infiltration by repressing IL-6 production to facilitate tumor immune evasion in breast cancer.