Integrated computational screening and liquid biopsy approach to uncover the role of biomarkers for oral cancer lymph node metastasis.

ABSTRACT: Cancer is an abnormal, heterogeneous growth of cells with the ability to invade surrounding tissue and even distant organs. Worldwide, GLOBOCAN had an estimated 18.1 million new cases and 9.6 million death rates of cancer in 2018. Among all cancers, Oral cancer (OC) is the sixth most common cancer worldwide, and the third most common in India, the most frequent type, oral squamous cell carcinoma (OSCC), tends to spread to lymph nodes in advanced stages. Throughout the past few decades, the molecular landscape of OSCC biology has remained unknown despite breakthroughs in our understanding of the genome-scale gene expression pattern of oral cancer particularly in lymph node metastasis. Moreover, due to tissue variability in single-cohort studies, investigations on OSCC gene-expression profil

SUBMITTER: Shaikh S 

PROVIDER: S-EPMC10462753 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature