Insight into the regulatory mechanism of dynamic chromatin 3D interactions during cardiomyocyte differentiation in human.

ABSTRACT: Cardiogenesis is an extremely complicated process involved with DNA regulatory elements, and trans factors regulate gene expression pattern spatiotemporally. Enhancers, as the well-known DNA elements, activate target gene expression by transcription factors (TFs) occupied to organize dynamic three-dimensional (3D) interactions, which when affected or interrupted might cause heart defects or diseases. In this study, we integrated transcriptome, 3D genome, and regulatome to reorganize the global 3D genome in cardiomyogenesis, showing a gradually decreased trend of both chromatin interactions and topological associating domains (TADs) during cardiomyocyte differentiation. And almost all of the chromatin interactions occurred within the same or between adjacent TADs involved with enhanc

SUBMITTER: Liu H 

PROVIDER: S-EPMC10462852 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature