Persistence of antibody responses to COVID-19 vaccines among participants in the COVID-19 Community Research Partnership.

ABSTRACT:

Introduction

High levels of immunity to SARS-CoV-2 in the community correlate with protection from COVID-19 illness. Measuring COVID-19 antibody seroprevalence and persistence may elucidate the level and length of protection afforded by vaccination and infection within a population.

Methods

We measured the duration of detectable anti-spike antibodies following COVID-19 vaccination in a multistate, longitudinal cohort study of almost 13,000 adults who completed daily surveys and submitted monthly dried blood spots collected at home.

Results

Overall, anti-spike antibodies persisted up to 284 days of follow-up with seroreversion occurring in only 2.4% of the study population. In adjusted analyses, risk of seroreversion increased with age (adults aged 55-64: adjusted haza

SUBMITTER: Berry AA 

PROVIDER: S-EPMC10462856 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature