Shared genetic architecture of blood eosinophil counts and asthma in UK Biobank.

ABSTRACT:

Rationale

Asthma is a complex, heterogeneous disease strongly associated with type 2 inflammation, and blood eosinophil counts guide therapeutic interventions in moderate and severe asthma. Eosinophils are leukocytes involved in type 2 immune responses. Despite these critical associations between asthma and blood eosinophil counts, the shared genetic architecture of these two traits remains unknown. The objective of the present study was to characterise the genetic architecture of blood eosinophil counts and asthma in the UK Biobank.

Methods

We performed genome-wide association studies (GWAS) of doctor-diagnosed asthma, blood eosinophil, neutrophil, lymphocyte and monocyte counts in the UK Biobank. Genetic correlation analysis was performed on GWAS results and validated in t

SUBMITTER: Li B 

PROVIDER: S-EPMC10463033 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature