Antibiotics in pregnancy influence nasal microbiome and respiratory morbidity in infancy.

ABSTRACT:

Background

The effects of prenatal antibiotic exposure on respiratory morbidity in infancy and the involved mechanisms are still poorly understood. We aimed to examine whether prenatal antibiotic exposure in the third trimester is associated with nasal microbiome and respiratory morbidity in infancy and at school age, and whether this association with respiratory morbidity is mediated by the nasal microbiome.

Methods

We performed 16S ribosomal RNA gene sequencing (regions V3-V4) on nasal swabs obtained from 296 healthy term infants from the prospective Basel-Bern birth cohort (BILD) at age 4-6 weeks. Information about antibiotic exposure was derived from birth records and standardised interviews. Respiratory symptoms were assessed by weekly telephone interviews in the first

SUBMITTER: Ruttimann C 

PROVIDER: S-EPMC10463034 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature