Muvalaplin, an Oral Small Molecule Inhibitor of Lipoprotein(a) Formation: A Randomized Clinical Trial.

ABSTRACT:

Importance

Lipoprotein(a) (Lp[a]) is associated with atherosclerotic disease and aortic stenosis. Lp(a) forms by bonding between apolipoprotein(a) (apo[a]) and apo B100. Muvalaplin is an orally administered small molecule that inhibits Lp(a) formation by blocking the apo(a)-apo B100 interaction while avoiding interaction with a homologous protein, plasminogen.

Objective

To determine the safety, tolerability, pharmacokinetics, and pharmacodynamic effects of muvalaplin.

Design, setting, and participants

This phase 1 randomized, double-blind, parallel-design study enrolled 114 participants (55 assigned to a single-ascending dose; 59 assigned to a multiple-ascending dose group) at 1 site in the Netherlands.

Interventions

The single ascending dose treatment evaluate

SUBMITTER: Nicholls SJ 

PROVIDER: S-EPMC10463176 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature