ORMDL3‑mediated bronchial epithelial pyroptosis leads to lung inflammation in obese mice with asthma.

ABSTRACT: Asthma associated with obesity is a chronic disease that poses a threat to health in children and results in severe wheezing, earlier airway remodeling and increased insensitivity to hormone therapy compared with those who only have asthma. Despite its clinical importance, knowledge on the underlying mechanisms of this disease is limited. The present study aimed to elucidate the pathogenesis of asthma associated with obesity using a murine model. A total of 30 female BALB/c mice were divided into three groups: Normal, mice with asthma and obese mice with asthma. Obese mice with asthma were fed a high‑fat diet to induce obesity. Mice with asthma were sensitized and challenged with ovalbumin (OVA). Obese mice were subjected to OVA sensitization and challenge to develop asthma associated with

SUBMITTER: Liu F 

PROVIDER: S-EPMC10463223 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature